EPA Science Advisory Board (SAB)

All-Ages Lead Model: Evaluation of the Theoretical Framework and Model

EPA Designated Federal Officer (DFO):Iris Goodman
202-564-2164
goodman.iris@epa.gov
Responsible Committee/Panel:Ad Hoc Panel Being Formed

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BACKGROUND
The U.S. EPA requested the SAB to conduct a peer review of the All-Ages Lead Model (AALM). The Agency's Office of Research and Development (ORD) in collaboration with Office of Chemical Safety and Pollution Prevention (OCSPP) developed the AALM to provide a tool for rapidly evaluating the impact of possible sources of lead on blood and other tissue levels in humans from birth to 90 years of age. The AALM predicts lead concentration in body tissues and organs for a hypothetical individual, based on a simulated lifetime of lead exposure.

The AALM is an outgrowth of the Integrated Exposure Uptake Biokinetic (IEUBK) Model for Lead in Children. Version 0.99d of the IEUBK was released in 1994 and has been widely accepted in the risk assessment community as a tool for implementing the site-specific risk assessment process when the issue is childhood lead exposure. The IEUBK model was designed to assess changes in blood lead of children over periods of no less than a month. The AALM was developed to cover childhood and adult lead exposures and allows users to assess the effects of intermittent lead exposures of a day or more as well as stable exposure conditions.