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|The National Center for Environmental Assessment (NCEA) in the EPA's Office of Research and Development (ORD) develops toxicological reviews/assessments for various chemicals for inclusion in the IRIS database. NCEA is developing a draft Toxicological Review of tert-Butyl Alcohol (tert-butanol) and Toxicological Review of Ethyl Tertiary Butyl Ether (ETBE) and has asked the SAB to conduct the peer review of these draft documents.|
These two draft EPA documents represent new IRIS assessments of tert-butanol and ETBE. Experimental animal data and other relevant data from studies of the noncancer and cancer effects of tert-butanol and ETBE are evaluated in these assessments. These assessments include an oral reference dose (RfD) and inhalation reference concentration (RfC) for noncancer effects as well as a cancer assessment. The cancer assessments characterize tert-butanol and ETBE as having suggestive evidence of carcinogenic potential to humans and include oral cancer slope factors for both compounds and an inhalation unit risk for ETBE.