Project Title & Description
Devel. of a Physiologically Based Pharmacokinetic/ Pharmacodynamic Model to Quantitate Biomarkers -
To develop models to quantify acetylcholinesterase (AChE) inhibition in young rats and children for the organophosphate (OP), insecticide chlorpyrifos (CPF). It is hypothesized that an age-dependent decrement in detoxification of OPs correlates with the increased sensitivity of young animals to OPs. The model will integrate age-dependent changes in metabolism and response and will facilitate biomonitoring for OP exposures.