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Project Title: Devel. of a Physiologically Based Pharmacokinetic/ Pharmacodynamic Model to Quantitate Biomarkers -

Hide details for Grant InformationGrant Information

Grant ID Number:R - 82860801-2
EPA Region:EPA HQAAShip:ORD - Office of Research and Development
Division/Office:NCERLab/Office:
CFDA:66.500Media:Pesticides
Grant Program:
Authority:
Recipient Name: Battelle Memorial Institute Pacific N.W. Divison
City:Recipient Type:Not for Profit
State:WACong District:04
DUNS:004492575
Competition Status:
Award Date:05/17/2005Cum Award:$733,174
Project Start:04/01/2001Project End:05/31/2005
Hide details for Project Title & DescriptionProject Title & Description

Devel. of a Physiologically Based Pharmacokinetic/ Pharmacodynamic Model to Quantitate Biomarkers -
To develop models to quantify acetylcholinesterase (AChE) inhibition in young rats and children for the organophosphate (OP), insecticide chlorpyrifos (CPF). It is hypothesized that an age-dependent decrement in detoxification of OPs correlates with the increased sensitivity of young animals to OPs. The model will integrate age-dependent changes in metabolism and response and will facilitate biomonitoring for OP exposures.



Hide details for Contact InformationContact Information

RoleNamePhone
Project Officer Kathleen Deener 202-343-9852
Grant Specialist Rahsaan Tabb 202-564-5376

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