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The EPA's Office of Research and Development (ORD) has developed a draft “IRIS Toxicological Review of Trimethylbenzenes “(August 2013), the first IRIS assessment developed for trimethylbenzenes, including 1,2,3-TMB; 1,2,4-TMB; 1,3,5-TMB. For this assessment, ORD evaluated experimental animal data and other relevant noncancer data The assessment includes an inhalation reference concentration, oral reference dose, and qualitative cancer descriptor for each isomer. The assessment does not include a quantitative cancer assessment
ORD has requested SAB peer review of its August 2013 toxicological review of trimethylbenzenes.