The EPA is currently in the process of updating the 1988 IRIS cancer assessment for inorganic arsenic (iAs). The EPA evaluated and implemented the National Research Council recommendations in their report titled “Arsenic in Drinking Water: 2001 Update” and in 2005 requested the SAB review the Agency’s draft cancer assessment for iAs. The SAB review report was finalized in 2007.
EPA’s Office of Research Development has recently completed a 2010 draft titled: “Toxicological Review of Inorganic Arsenic: In Support of the Summary Information on the Integrated Risk Information System (IRIS)”. The draft assessment includes an evaluation and characterization of the potential cancer hazard of iAs and a quantitative dose-response cancer assessment for iAs. The draft assessment also provides a disposition of SAB’s previous review comments and recommendations.
In response to a request from the EPA Administrator, ORD has asked the SAB evaluate and comment on EPA’s interpretation and implementation of the key SAB (2007) recommendations in the revised draft assessment. ORD is requesting an expedited and focused review of the draft assessment in three areas: evaluation of epidemiological literature; dose-response modeling approaches; and the sensitivity analysis of the exposure assumptions used in the risk assessment.