Jump to main content.



Inorganic Arsenic - Toxicological Review for IRIS

EPA Designated Federal Officer (DFO):Suhair Shallal
202-564-2057
shallal.suhair@epa.gov

Responsible Committee/Panel:Work Group of the Chartered SAB for the Arsenic Cancer Review
A list of members can be found in the final report included in the Advisory Activity linked to this panel or committee.

PLEASE NOTE: Some of the items mentioned in this page are in Adobe's Portable Document Format (PDF). To view or print them you will need to have the Adobe Acrobat Reader program installed on your computer. The Reader can be downloaded and used with no charge. Click here for more information from EPA on PDF files.
 

BACKGROUND.

The EPA is currently in the process of updating the 1988 IRIS cancer assessment for inorganic arsenic (iAs). The EPA evaluated and implemented the National Research Council recommendations in their report titled “Arsenic in Drinking Water: 2001 Update” and in 2005 requested the SAB review the Agency’s draft cancer assessment for iAs. The SAB review report was finalized in 2007.

EPA’s Office of Research Development has recently completed a 2010 draft titled: “Toxicological Review of Inorganic Arsenic: In Support of the Summary Information on the Integrated Risk Information System (IRIS)”. The draft assessment includes an evaluation and characterization of the potential cancer hazard of iAs and a quantitative dose-response cancer assessment for iAs. The draft assessment also provides a disposition of SAB’s previous review comments and recommendations.

In response to a request from the EPA Administrator, ORD has asked the SAB evaluate and comment on EPA’s interpretation and implementation of the key SAB (2007) recommendations in the revised draft assessment. ORD is requesting an expedited and focused review of the draft assessment in three areas: evaluation of epidemiological literature; dose-response modeling approaches; and the sensitivity analysis of the exposure assumptions used in the risk assessment.

Agency Review Document(s):

PDF for IRIS Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft). (PDF, 575 pp., 7,013,063 bytes)


Local Navigation



Jump to main content.