EPA Science Advisory Board (SAB)

IRIS Assessment for Benzo[a]pyrene

EPA Designated Federal Officer (DFO):Diana Wong
Responsible Committee/Panel:Chemical Assessment Advisory Committee Augmented for the Review of Draft IRIS Benzo[a]pyrene Assessment

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EPA’s Office of Research and Development has developed a draft Toxicological Review of Benzo[a]pyrene (September 2014), which updates a 1987 assessment of the toxicity of benzo[a]pyrene posted to the IRIS database. The 2014 draft assessment contains a qualitative characterization of the hazards for benzo[a]pyrene, including a cancer descriptor of the chemical’s human carcinogenic potential, cancer risk estimates for oral, inhalation and dermal exposure, and noncancer toxicity values for chronic oral (reference dose) and inhalation (reference concentration) exposure. The draft assessment also includes the IRIS Program’s first dermal slope factor. ORD has requested SAB peer review of its September 2014 draft toxicological review for benzo[a]pyrene.

Agency Charge . (PDF, 3 pp., 123,882 bytes)

Agency Review Document(s):

PDF for Toxicological Review of Benzo[a]pyrene, External Review Draft (September, 2014). (PDF, 216 pp., 3,427,368 bytes)

PDF for Toxicological Review of Benzo[a]pyrene, External Review Draft, Supplemental Information (September 2014). (PDF, 334 pp., 4,886,756 bytes)

PDF for Toxicological Review of Benzo[a]pyrene, Note to Reviewers 9-25-14. (PDF, 2 pp., 274,265 bytes)

EPA background information related to the review document:

IRIS Toxicological Review of Benzo[a]pyrene (External Review Draft) (September 2014)