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Chemical Emergency Preparedness and Prevention
 
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Background

The U.S. Environmental Protection Agency has developed a set of chemical profile reference documents for use in dealing with Section 302 of Title III of the Superfund Amendments and Reauthorization Act (SARA). These EPA profiles contain a summary of publicly available documented information for chemicals on the EPA list of extremely hazardous substances listed in the Federal Register, Vol. 52, No. 77, April 22, 1987.

The profiles were originally developed in 1985 for the 402 chemicals then called "acutely toxic chemicals" under the Chemical Emergency Preparedness Program. When the list went into law as the list of extremely hazardous substances, four additional chemicals were included. Forty of the 406 chemicals were subsequently deleted from the list. Profiles are provided for the 366 chemicals listed in February, 1988, as extremely hazardous substances. Other chemicals may be added or deleted in the future. The profile format was revised and the data were reviewed, augmented, and revised as appropriate in 1987. The profiles have been reviewed for accuracy and completeness. However, an exhaustive literature search was not performed for each chemical, and a review of original citations has not been made.

A profile is provided for each chemical on the list of extremely hazardous substances. Profiles are presented in ascending order of Chemical Abstract Service (CAS) registry numbers. One chemical (generic name: organorhodium complex) is identified by a premanufacture review notice (PMN) number and appears first.

The CAS number was used to search the automated Toxicology Data Base (TDB) or Hazardous Substance Data Bank (HSDB) from the National Library of Medicine (NLM). If available, TDB/HSDB files were retrieved. Approximately 65 percent of the chemicals were listed in the TDB/HSDB files. For these chemicals, the TDB/HSDB files provided the main source of information for the profiles. All data obtained from the TDB/HSDB were indicated by an asterisk (*) followed by a reference to the TDB/HSDB citation, (e.g., (*Merck 1976)). For those chemicals without a TDB/HSDB file, a limited number of standard reference materials was searched. Such references are cited by author, year, and page number. A master list of references, including the secondary references cited in TDB/HSDB, has been prepared and may be found in the Reference Section of this document. The abbreviations used in the profiles have been defined in a master list and may be found in the Abbreviation Section. Medical terms not commonly used have been included in a Glossary Section. Dorland's Medical Dictionary (1974) was used to provide most of the definitions in the Glossary.

If information was not available for a specific compound but the chemical could be categorized, then general information about the chemical category was included. Such information is indicated, for example, by the notation "Non-Specific - - Organophosphorus Pesticide" or "Non-Specific-- Poisonous Solid, n.o.s."

 

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