1.0 Submitter/Company Information
Submitting Company: HOOKER CHEM CO

Submitter Comments


2.0 Submission Information

Submission Stage: INI

Document Control Number: 40790052012

Microfiche Number: OTS0508138

3.0 Chemical Information
CAS Number: 98-56-6

TSCA Chemical Inventory Name: Benzene, 1-chloro-4-(trifluoromethyl)-

Synonyms: 4-(TRIFLUOROMETHYL)CHLOROBENZENE

Other Chemicals in Submission:

4.0 Study Information
Study Title:
ACUTE ORAL TOXICITY (LD50) IN ALBINO RATS

Study Information:
Acute/Subacute Toxicity
Unknown Environmental Effects

Summary/Abstract:
[Raltech Scientific Services Inc.; Acute Oral Toxicity (LD50) in Albino Rats (1979), EPA Document No. 40-7952012, Fiche No. OTS0508138] Acute oral toxicity was evaluated in a single group of 16 Sprague-Dawley rats (8 male and 8 female) administered undiluted parachlorobenzotrifluoride by oral gavage in the amount of 5.0 ml/kg body weight. Mortality was observed in 2 males, and the LD50 value was estimated to be greater than 5 ml/kg in both males and females. Clinical observations included hypoactivity, tremors, ataxia, decreased limb tone, loss of righting reflex, blood on nose, lacrimation, hypothermia, hostility, and piloerection. The following observations were reported after gross necropsy of decedents and survivors: hemorrhagic areas in thymus; dark lungs with white foci; white foci on lungs; and a solid mass in the uterus of one female.