1.0 Submitter/Company Information
Submitting Company: OCCIDENTAL CHEMICAL CORPORATION

Voluntary Submitter Actions: OTHS
NO VOLUNTARY ACTIONS REPORTED

2.0 Submission Information
Submission Date: 02/21/92

EPA Receipt Date: 02/28/92

8(e)/FYI ID Number: 8EHQ-0292-02490A

Submission Stage: INI

Document Control Number: 88920001132

3.0 Chemical Information
CAS Number: 13560-89-9

TSCA Chemical Inventory Name: 1,4:7,10-Dimethanodibenzo[a,e]cyclooctene, 1,2,3,4,7,8,9,10,13,13,14,14-dodecachloro-1,4,4a,5,6,6a,7,10,10a,11,12,12a-dodecahydro-

Synonyms: DECHLORANE PLUS 515
DECHLORANE PLUS 25

Other Chemicals in Submission:

4.0 Study Information

Study Information:
NEUROTOXICITY (ANIMAL) ACUTE TOXICITY (ANIMAL) FINAL RESULTS SUB
Acute/Subacute Toxicity
Unknown Environmental Effects
EF

Summary/Abstract:
ACUTE ORAL TOXICITY IN RATS IS LOW CONCERN WITH AN LD50 > 25 G/KG. ACUTE
DERMAL TOXICITY IN RABBITS IS LOW CONCERN WITH AN LD50 > 8 G/KG. ACUTE
INHALATION TOXICITY IS LOW CONCERN WITH AN LC50 > 2.25 MG/L. DERMAL IRRITATION
IS LOW CONCERN. NO SKIN IRRITATION WAS NOTED. EYE IRRITATION IN RABBITS IS
LOW CONCERN. NO EYE IRRITATION IS NOTED. SKIN SENSITIZATION IN RABBITS IS LOW
CONCERN. THE TEST MATERIAL CAUSED NO SKIN SENSITIZATION.

28 DAY DERMAL TOXICITY IN RABBITS IS LOW CONCERN. REDUCED OVARY WEIGHT WAS
NOTED AT 500 AND 1000 MG/KG. NO HISTOPATHOLOGY WAS REPORTED. 28 DAY
INHALATION TOXICITY IN RAT IS LOW CONCERN. ANIMALS WERE EXPOSED TO TEST
MATERIAL FOR 6 HOURS/DAY, 5 DAYS/WEEK FOR 4 WEEKS. AT 640 AND 1524 MG/M3,
INCREASED LIVER AND LUNG WEIGHTS WERE NOTED. EFFECTS NOTED INCLUDED INCREASED
NUMBER OF PULMONARY MACROPHAGE, HEPATOCYTOMEGALY OF CENTRILOBULAR HEPATOCYTES
(IN ALL MALES AND 2/5 FEMALES AT THE HIGH DOSE).

90 DAY FEEDING TOXICITY IN RAT IS LOW CONCERN. ANIMALS WERE DOSED WITH 1, 3
AND 10% CONCENTRATIONS OF THE TEST MATERIAL. INCREASED LIVER WEIGHTS WERE
NOTED AT THE 10% DOSAGE LEVEL.